This definitely is a film for those interested in neuropsychology. Leonard has anterograde amnesia (he can't form new memories). To compensate, he tattoos notes to himself all over his body. He is on a quest to find the person who raped and murdered his wife. You'll have to watch this one closely to follow the plot -- it is told in reverse. The attempt to accurately portray anterograde amnesia should be commended, but there are several points where Leonard acts as if he has "held" a memory longer than could be working memory alone (e.g., he sleeps between the event and writing it down). What else can you find that is inaccurate? What about the failed avoidance learning by the insurance claimant?
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